Choline kinase alpha

A choline kinase alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35790]

Synonyms

CK;
EC 2.7.1.32;
CHETK-alpha;
Ethanolamine kinase;
EK;
2.7.1.82

Research

Bioassay Publications (3)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (33.33)	29.6817
2010's	1 (33.33)	24.3611
2020's	1 (33.33)	2.80

Compounds (3)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
rsm-932a	Homo sapiens (human)	IC50	1.9600	2	2

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
4-dimethylaminopyridine	Homo sapiens (human)	Kd	35.0000	1	1
4-pyrrolidinopyridine	Homo sapiens (human)	Kd	49.0000	1	1

Enables

This protein enables 6 target(s):

Target	Category	Definition
choline kinase activity	molecular function	Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H+. [EC:2.7.1.32, RHEA:12837]
cholinesterase activity	molecular function	Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion. [EC:3.1.1.8]
ethanolamine kinase activity	molecular function	Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H+ + phosphoethanolamine. [EC:2.7.1.82, RHEA:13069]
protein tyrosine kinase activity	molecular function	Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. [RHEA:10596]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
protein homodimerization activity	molecular function	Binding to an identical protein to form a homodimer. [GOC:jl]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
lipid droplet	cellular component	An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. [GOC:mah, GOC:tb]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 5 target(s):

Target	Category	Definition
lipid metabolic process	biological process	The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. [GOC:ma]
phosphatidylethanolamine biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. [ISBN:0198506732]
phosphatidylcholine biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. [ISBN:0198506732]
lipid transport	biological process	The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. [ISBN:0198506732]
CDP-choline pathway	biological process	The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine. [ISBN:0471331309, MetaCyc:PWY3O-450]