dUTP diphosphatase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: dUTP + H2O = dUMP + H+ + diphosphate. [RHEA:10248]

dUTP diphosphatase activity catalyzes the hydrolysis of dUTP to dUMP and inorganic pyrophosphate. This reaction is essential for maintaining the integrity of DNA by preventing the incorporation of uracil into DNA. Uracil is a normal component of RNA but is not found in DNA. If uracil is incorporated into DNA, it can lead to mutations and other genomic instability. dUTP diphosphatase is therefore an important enzyme in the DNA repair pathway. The enzyme is highly specific for dUTP and does not hydrolyze other nucleoside triphosphates. It is also inhibited by inorganic pyrophosphate, the product of the reaction. dUTP diphosphatase is found in all living organisms and is essential for cell survival. It is typically located in the cytoplasm and nucleus, where it can access dUTP and DNA, respectively.'
"

Proteins (1)

Compounds (1)