Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

A deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:P33316]

dUTPase;
EC 3.6.1.23;
dUTP pyrophosphatase

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
2',3'-didehydro-2',3'-dideoxyuridine	Homo sapiens (human)	Ki	1,000.0000	1	1

This protein enables 4 target(s):

Target	Category	Definition
RNA binding	molecular function	Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]
dUTP diphosphatase activity	molecular function	Catalysis of the reaction: dUTP + H2O = dUMP + H+ + diphosphate. [RHEA:10248]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
magnesium ion binding	molecular function	Binding to a magnesium (Mg) ion. [GOC:ai]

This protein is located in 3 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
mitochondrion	cellular component	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

This protein is active in 1 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

This protein is involved in 5 target(s):

Target	Category	Definition
nucleobase-containing compound metabolic process	biological process	Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. [GOC:ai]
dUMP biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of dUMP, deoxyuridine monophosphate (2'-deoxyuridine 5'-phosphate). [ISBN:0198506732]
dTMP biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate). [ISBN:0198506732]
DNA replication	biological process	The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. [GOC:mah]
dUTP catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate. [GOC:go_curators]