Target type: molecularfunction
Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H+. [EC:2.7.1.32, RHEA:12837]
Choline kinase activity is the enzymatic catalysis of the phosphorylation of choline to produce phosphocholine. This reaction is the first committed step in the biosynthesis of phosphatidylcholine, a major component of cell membranes. Choline kinases utilize ATP as a phosphate donor, and the reaction mechanism typically involves the formation of a phosphorylated enzyme intermediate. This intermediate then transfers the phosphate group to choline. The choline kinase family comprises several isoforms, each with its own specific cellular localization and regulatory properties. These isoforms play diverse roles in cellular processes, including membrane biogenesis, signal transduction, and cell proliferation. In addition to its role in phosphatidylcholine synthesis, phosphocholine can also serve as a precursor for other important molecules, such as CDP-choline and sphingomyelin.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Choline kinase alpha | A choline kinase alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35790] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| 4-dimethylaminopyridine | 4-dimethylaminopyridine: catalyst for acetylation of hydroxy cpds; structure | dialkylarylamine; tertiary amino compound | |
| 4-pyrrolidinopyridine | |||
| rsm-932a | RSM-932A: a choline kinase inhibitor with antimalarial activity; structure in first source |