Target type: molecularfunction
Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate. [EC:5.4.2.4]
Bisphosphoglycerate mutase activity catalyzes the reversible interconversion of 1,3-bisphosphoglycerate (1,3-BPG) and 2,3-bisphosphoglycerate (2,3-BPG). This reaction is essential in red blood cells for regulating the oxygen affinity of hemoglobin. 1,3-BPG is a substrate in the glycolytic pathway, while 2,3-BPG is an allosteric effector of hemoglobin. The enzyme utilizes a phosphoryl transfer reaction mechanism, where the phosphate group from 1,3-BPG is temporarily transferred to an active site histidine residue before being transferred to the 2-position of the glycerate molecule. This reaction involves a conformational change in the enzyme, which facilitates the transfer of the phosphate group. The enzyme has a strict requirement for divalent metal ions such as Mg2+ or Mn2+, which are involved in stabilizing the transition state and facilitating the phosphoryl transfer. The activity of bisphosphoglycerate mutase is regulated by factors such as pH, temperature, and the concentration of substrates and products. Additionally, the enzyme is subject to post-translational modifications such as phosphorylation, which can affect its activity. In red blood cells, the activity of this enzyme is tightly controlled to maintain the appropriate levels of 2,3-BPG, which is crucial for oxygen delivery to tissues.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Phosphoglycerate mutase 1 | A phosphoglycerate mutase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P18669] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| xanthone | xanthone : The parent compound of the xanthone class consisting of xanthene bearing a single oxo substituent at position 9. | xanthones | insecticide |
| epigallocatechin gallate | (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin. epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis) | flavans; gallate ester; polyphenol | antineoplastic agent; antioxidant; apoptosis inducer; geroprotector; Hsp90 inhibitor; neuroprotective agent; plant metabolite |
| alizarin red s | alizarin red S : An organic sodium salt having 3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate as the counterion. It is commonly used to stain embryo skeletons in cleared whole mounts, usually of small mammals. Alizarin Red S: RN given refers to parent cpd; structure | organic sodium salt; organosulfonate salt | histological dye |
| mangostin | alpha-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities. mangostin: xanthone from rind of Garcinia mangostana Linn. fruit | aromatic ether; phenols; xanthones | antimicrobial agent; antineoplastic agent; antioxidant; plant metabolite |
| gamma-mangostin | gamma-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3, 6 and 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antitumour activity. | phenols; xanthones | antineoplastic agent; plant metabolite; protein kinase inhibitor |