Target type: molecularfunction
Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H+. [EC:2.7.2.4, RHEA:23776]
Aspartate kinase activity is a fundamental enzymatic process in amino acid biosynthesis, specifically the production of the amino acid lysine. This activity is catalyzed by aspartate kinases, which are responsible for the first committed step in lysine biosynthesis. The reaction involves the phosphorylation of L-aspartate to yield beta-aspartyl phosphate, using ATP as the phosphate donor. This phosphorylation reaction is highly regulated, serving as a critical control point for the flux of metabolites into the lysine biosynthetic pathway. Aspartate kinase activity is essential for maintaining appropriate lysine levels within cells, which are required for numerous cellular processes, including protein synthesis, DNA replication, and cell signaling.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Bifunctional aspartokinase/homoserine dehydrogenase 1 | A bifunctional aspartokinase/homoserine dehydrogenase 1 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P00561] | Escherichia coli K-12 |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| glutamic acid | glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2. Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM. | glutamic acid; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid | Escherichia coli metabolite; ferroptosis inducer; micronutrient; mouse metabolite; neurotransmitter; nutraceutical |
| beta-aminoglutaric acid | 3-aminoglutaric acid: RN given refers to parent cpd; structure given in first source isoglutamic acid : A 1,5-dicarboxylic acid compound having a 3-amino substituent. It has been isolated from the extracts of the algae, Chondria armata. | dicarboxylic acid | algal metabolite; marine metabolite |