UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol. [EC:2.7.8.15]

UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity is an essential enzyme in the biosynthesis of N-linked glycans, which are complex sugar structures that are attached to proteins. This enzyme catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to dolichyl-phosphate-GlcNAc, forming dolichyl-pyrophosphate-GlcNAc2. This reaction is the first committed step in the assembly of the lipid-linked oligosaccharide precursor for N-glycosylation. The enzyme is highly conserved across species, and mutations in the gene encoding this enzyme can lead to a variety of human diseases, including congenital disorders of glycosylation. The enzyme requires the presence of both UDP-GlcNAc and dolichyl-phosphate-GlcNAc as substrates. The reaction proceeds via a two-step mechanism: 1) the enzyme binds both substrates, and 2) the enzyme transfers the GlcNAc from UDP-GlcNAc to dolichyl-phosphate-GlcNAc, forming dolichyl-pyrophosphate-GlcNAc2 and UDP. This enzyme is involved in a variety of cellular processes, including protein folding, cell signaling, and immune responses. It is also important for the synthesis of glycoproteins, which are proteins that have sugar chains attached to them. These glycoproteins play a variety of roles in the body, including cell recognition, cell adhesion, and immune system function.'
"

Proteins (2)

Compounds (1)