N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity
Definition
Target type: molecularfunction
Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H+. [EC:3.5.1.26, RHEA:11544]
N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity refers to the enzymatic hydrolysis of the glycosidic bond between N-acetylglucosamine and asparagine in the N-linked glycans of glycoproteins. This activity is critical for the processing and maturation of glycoproteins, which play diverse roles in cell signaling, immune function, and protein folding. Specifically, this enzyme removes the terminal N-acetylglucosamine residue from the N-linked glycan, a step essential for the subsequent processing by other glycosidases. The resulting oligosaccharide chain then undergoes further modifications, including trimming, branching, and the addition of other sugars, leading to the formation of diverse and functionally relevant glycan structures.'
"
Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase | An N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P20933] | Homo sapiens (human) |
Compounds (6)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| succinic acid | succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle. Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851) | alpha,omega-dicarboxylic acid; C4-dicarboxylic acid | anti-ulcer drug; fundamental metabolite; micronutrient; nutraceutical; radiation protective agent |
| 2-amino-3-phosphonopropionic acid | 2-amino-3-phosphonopropanoic acid : A non-proteinogenc alpha-amino acid that is alanine in which one of the hydrogens of the terminal methyl group has been replaced by a dihydroxy(oxido)-lambda(5)-phosphanyl group. 2-amino-3-phosphonopropionic acid: metabotropic glutamate receptor antagonist; do not confuse AP-3 used as an abbreviation for this with enhancer-binding protein AP-3 (a trans-activator) or clathrin assembly protein AP-3 | alanine derivative; non-proteinogenic alpha-amino acid; phosphonic acids | human metabolite; metabotropic glutamate receptor antagonist |
| aspartic acid | aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter. L-aspartic acid : The L-enantiomer of aspartic acid. | aspartate family amino acid; aspartic acid; L-alpha-amino acid; proteinogenic amino acid | Escherichia coli metabolite; mouse metabolite; neurotransmitter |
| monomethyl succinate | 2-methylbutanedioic acid : A dicarboxylic acid that is butanedioic acid substituted at position 2 by a methyl group. methylsuccinic acid : A racemate comprising equimolar amounts of (R)- and (S)-methylsuccinic acid methylsuccinic acid: RN given refers to cpd without isomeric designation | dicarboxylic acid | |
| cysteic acid | cysteic acid : An amino sulfonic acid that is the sulfonic acid analogue of cysteine. Cysteic Acid: Beta-Sulfoalanine. An amino acid with a C-terminal sulfonic acid group which has been isolated from human hair oxidized with permanganate. It occurs normally in the outer part of the sheep's fleece, where the wool is exposed to light and weather. | alanine derivative; amino sulfonic acid; carboxyalkanesulfonic acid; cysteine derivative; non-proteinogenic alpha-amino acid | animal metabolite |
| bromosuccinic acid | bromosuccinic acid : A dicarboxylic acid that is succinic acid substituted at position 2 by a bromine atom. bromosuccinic acid: RN given refers to undesignated isomer | 2-bromocarboxylic acid; dicarboxylic acid |