Page last updated: 2024-10-24

N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H+. [EC:3.5.1.26, RHEA:11544]

N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity refers to the enzymatic hydrolysis of the glycosidic bond between N-acetylglucosamine and asparagine in the N-linked glycans of glycoproteins. This activity is critical for the processing and maturation of glycoproteins, which play diverse roles in cell signaling, immune function, and protein folding. Specifically, this enzyme removes the terminal N-acetylglucosamine residue from the N-linked glycan, a step essential for the subsequent processing by other glycosidases. The resulting oligosaccharide chain then undergoes further modifications, including trimming, branching, and the addition of other sugars, leading to the formation of diverse and functionally relevant glycan structures.'
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Proteins (1)

ProteinDefinitionTaxonomy
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginaseAn N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P20933]Homo sapiens (human)

Compounds (6)

CompoundDefinitionClassesRoles
succinic acidsuccinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.

Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
alpha,omega-dicarboxylic acid;
C4-dicarboxylic acid
anti-ulcer drug;
fundamental metabolite;
micronutrient;
nutraceutical;
radiation protective agent
2-amino-3-phosphonopropionic acid2-amino-3-phosphonopropanoic acid : A non-proteinogenc alpha-amino acid that is alanine in which one of the hydrogens of the terminal methyl group has been replaced by a dihydroxy(oxido)-lambda(5)-phosphanyl group.

2-amino-3-phosphonopropionic acid: metabotropic glutamate receptor antagonist; do not confuse AP-3 used as an abbreviation for this with enhancer-binding protein AP-3 (a trans-activator) or clathrin assembly protein AP-3
alanine derivative;
non-proteinogenic alpha-amino acid;
phosphonic acids
human metabolite;
metabotropic glutamate receptor antagonist
aspartic acidaspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent

Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.

L-aspartic acid : The L-enantiomer of aspartic acid.
aspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid
Escherichia coli metabolite;
mouse metabolite;
neurotransmitter
monomethyl succinate2-methylbutanedioic acid : A dicarboxylic acid that is butanedioic acid substituted at position 2 by a methyl group.

methylsuccinic acid : A racemate comprising equimolar amounts of (R)- and (S)-methylsuccinic acid

methylsuccinic acid: RN given refers to cpd without isomeric designation
dicarboxylic acid
cysteic acidcysteic acid : An amino sulfonic acid that is the sulfonic acid analogue of cysteine.

Cysteic Acid: Beta-Sulfoalanine. An amino acid with a C-terminal sulfonic acid group which has been isolated from human hair oxidized with permanganate. It occurs normally in the outer part of the sheep's fleece, where the wool is exposed to light and weather.
alanine derivative;
amino sulfonic acid;
carboxyalkanesulfonic acid;
cysteine derivative;
non-proteinogenic alpha-amino acid
animal metabolite
bromosuccinic acidbromosuccinic acid : A dicarboxylic acid that is succinic acid substituted at position 2 by a bromine atom.

bromosuccinic acid: RN given refers to undesignated isomer
2-bromocarboxylic acid;
dicarboxylic acid