N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose. [EC:3.1.4.45]

N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity catalyzes the hydrolysis of the phosphodiester bond between the terminal N-acetylglucosamine residue and the penultimate sugar residue in a N-glycan. This activity is essential for the degradation of N-glycans, which are complex oligosaccharide structures attached to proteins. The enzyme specifically recognizes and cleaves the alpha-1,4-linked N-acetylglucosamine residue from the core pentasaccharide of N-glycans. This activity plays a crucial role in the recycling of N-glycan precursors and in the regulation of N-glycosylation, a process that is critical for protein folding, stability, and function.'
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Proteins (1)

Compounds (1)