2-acylglycerol O-acyltransferase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol. [PMID:4016575, RHEA:16741]

2-acylglycerol O-acyltransferase activity catalyzes the transfer of an acyl group from an acyl donor, such as acyl-CoA, to the sn-1 position of 2-acylglycerol. This reaction is crucial for the synthesis of triacylglycerols (TAGs), the major storage form of fatty acids in animals and plants. The enzyme's catalytic mechanism involves the formation of a transient acyl-enzyme intermediate, followed by the transfer of the acyl group to the 2-acylglycerol substrate. The specificity of the enzyme for different acyl donors and acceptors can vary depending on the particular enzyme and its source. 2-acylglycerol O-acyltransferase activity plays a key role in lipid metabolism, particularly in the synthesis of TAGs for energy storage and membrane lipid biosynthesis. It is also involved in the regulation of lipid homeostasis and the modulation of cellular signaling pathways.'
"

Proteins (2)

Compounds (6)