Target type: molecularfunction
Catalysis of the reaction leukotriene C(4) + H2O= leukotriene D(4) + L-glutamate. [PMID:9774450, RHEA:31563]
Leukotriene-C4 hydrolase (LTC4H), also known as γ-glutamyltransferase, is a key enzyme involved in the metabolism of leukotrienes, a family of potent lipid mediators that play a crucial role in inflammatory and allergic responses. LTC4H catalyzes the hydrolysis of leukotriene C4 (LTC4) into leukotriene D4 (LTD4) and glutamate. LTC4 is a cysteinyl leukotriene, characterized by a cysteinyl residue attached to a γ-glutamyl residue, which forms an ester bond with the leukotriene molecule. LTC4H, as a γ-glutamyltransferase, specifically cleaves this γ-glutamyl residue, releasing glutamate and converting LTC4 to LTD4. This enzymatic reaction is essential for the biological activity of leukotrienes, as LTD4, unlike LTC4, can readily penetrate cell membranes and bind to CysLT1 and CysLT2 receptors, triggering a cascade of signaling events that mediate inflammation. LTD4 is a potent bronchoconstrictor and vasoconstrictor, and its production by LTC4H is a critical step in the development of asthma and other allergic diseases. Therefore, LTC4H serves as a crucial enzyme in the biosynthesis of LTD4, a key mediator of inflammatory and allergic responses, and its activity is a potential target for therapeutic intervention in asthma and other related conditions.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Glutathione hydrolase 1 proenzyme | A glutathione hydrolase 1 proenzyme that is encoded in the genome of human. [PRO:CNA, UniProtKB:P19440] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| aspirin | acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group. acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity. Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5) | benzoic acids; phenyl acetates; salicylates | anticoagulant; antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; drug allergen; EC 1.1.1.188 (prostaglandin-F synthase) inhibitor; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug; plant activator; platelet aggregation inhibitor; prostaglandin antagonist; teratogenic agent |