nociceptin receptor activity

Definition

Target type: molecularfunction

Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein. [GOC:bf, GOC:mah, PMID:18670432]

Nociceptin receptor activity is a molecular function that involves the binding of nociceptin, a neuropeptide, to its specific receptor, the nociceptin/orphanin FQ receptor (NOP receptor). This binding initiates a signaling cascade within the cell, leading to various physiological effects.

The NOP receptor is a G protein-coupled receptor (GPCR) belonging to the opioid receptor family. Upon nociceptin binding, the receptor undergoes conformational changes, activating associated G proteins. These G proteins, primarily of the Gαi/o subtype, trigger intracellular signaling pathways.

One primary pathway involves the inhibition of adenylyl cyclase, an enzyme responsible for the production of cyclic adenosine monophosphate (cAMP). Decreased cAMP levels can lead to the modulation of ion channels, including potassium channels, and influence neuronal excitability.

Another important pathway involves the activation of mitogen-activated protein kinases (MAPKs), such as extracellular signal-regulated kinases (ERK) and p38 MAPK. MAPK signaling plays a role in various cellular processes, including gene expression, cell growth, and differentiation.

Nociceptin receptor activity is implicated in a wide range of physiological functions, including pain modulation, anxiety, reward, and appetite regulation. It is believed to contribute to the analgesic effects of nociceptin, while also potentially playing a role in the development of addiction.

The precise molecular mechanisms underlying nociceptin receptor activity are still under investigation. However, ongoing research continues to unravel the intricate signaling pathways and physiological consequences associated with this important molecular function.'
"

Proteins (1)

Compounds (21)