neuromedin U receptor activity

Definition

Target type: molecularfunction

Combining with neuromedin U to initiate a change in cell activity. [GOC:ai]

Neuromedin U receptor activity is a molecular function associated with the binding of neuromedin U (NMU), a neuropeptide, to its cognate receptor, the neuromedin U receptor (NMUR). This binding event initiates a signaling cascade that regulates a variety of physiological processes. The NMU receptor is a G protein-coupled receptor (GPCR) belonging to the rhodopsin-like family. Upon NMU binding, the receptor undergoes conformational changes, leading to the activation of downstream signaling pathways, primarily through the coupling of the receptor to G proteins. The activated G proteins, particularly Gαq and Gαi, then activate phospholipase C (PLC), leading to the production of inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 mobilizes calcium from intracellular stores, while DAG activates protein kinase C (PKC). These intracellular signaling events ultimately result in a range of physiological responses, including modulation of appetite, energy expenditure, stress responses, and pain perception. In addition to the canonical G protein-mediated pathway, NMU receptor signaling can also involve interactions with other signaling molecules, such as β-arrestin and Src kinase, contributing to the diverse downstream effects of NMU receptor activation. The specific molecular mechanisms underlying these diverse functions are still being elucidated, but the NMU receptor plays a crucial role in the regulation of various physiological processes, making it a promising target for the development of new therapeutic strategies for various diseases.'
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Proteins (2)

Compounds (3)