intronic transcription regulatory region sequence-specific DNA binding

Definition

Target type: molecularfunction

Binding to an intronic DNA sequence that regulates the transcription of the transcript it is contained within. [GOC:txnOH]

Intronic transcription regulatory regions are DNA sequences located within introns that play a crucial role in regulating gene expression. These regions often bind to specific proteins, known as transcription factors, which can either activate or repress the transcription of the gene. The molecular function of intronic transcription regulatory region sequence-specific DNA binding involves the following steps:

1. **Recognition and binding:** Transcription factors contain specific DNA-binding domains that recognize and bind to short, specific DNA sequences within the intronic regulatory region. This recognition is highly specific, ensuring that the transcription factor binds only to its intended target sequences.

2. **Interaction with other proteins:** Once bound to the DNA, the transcription factor can interact with other proteins, such as co-activators or co-repressors, to modulate the transcription process. These interactions can lead to the recruitment of additional proteins, including RNA polymerase, which is responsible for transcribing the gene.

3. **Regulation of gene expression:** Depending on the specific transcription factor and its interaction with other proteins, the binding event can either activate or repress gene expression. Activators enhance the rate of transcription, while repressors inhibit it.

4. **Modulation of splicing:** Intronic transcription regulatory regions can also influence pre-mRNA splicing, the process of removing introns and joining exons to form mature mRNA. Transcription factors bound to these regions can interact with splicing factors, influencing the selection of splice sites and ultimately the final protein product.

5. **Chromatin remodeling:** Some transcription factors can induce changes in chromatin structure, making the DNA more or less accessible to other proteins. This can impact the efficiency of transcription and the overall expression of the gene.

In summary, intronic transcription regulatory region sequence-specific DNA binding involves the recognition and binding of specific DNA sequences by transcription factors, leading to the modulation of gene expression, pre-mRNA splicing, and chromatin remodeling.'
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Proteins (1)

Compounds (3)