Target type: molecularfunction
Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus. [EC:5.4.99.7, RHEA:14621]
Lanosterol synthase activity catalyzes the cyclization of (S)-2,3-oxidosqualene to lanosterol, a key step in the biosynthesis of sterols. This reaction involves a complex series of rearrangements and cyclizations, starting with the opening of the epoxide ring of (S)-2,3-oxidosqualene and culminating in the formation of the tetracyclic lanosterol molecule. The reaction proceeds through a series of carbocation intermediates, and is highly stereospecific, resulting in the formation of a specific configuration of the sterol molecule. Lanosterol synthase is a highly conserved enzyme, with homologs found in all eukaryotes. It is essential for the synthesis of cholesterol and other sterols, which play critical roles in cellular membrane structure, signaling, and hormone biosynthesis. The activity of lanosterol synthase is tightly regulated, and dysregulation of this enzyme can lead to various human diseases, including genetic disorders and cancer.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Lanosterol synthase | A lanosterol synthase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48449] | Homo sapiens (human) |
| Lanosterol synthase | A lanosterol synthase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48449] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| ro 48-8071 | Ro 48-8071 : An aromatic ketone that is 2-fluoro-4'-bromobenzophenone in which the hydrogen at position 4 (meta to the fluoro group) is replaced by a 6-[methyl(prop-2-en-1-yl)amino]hexyl}oxy group. An inhibitor of lanosterol synthase. Ro 48-8071: a cholesterol synthesis inhibitor; structure in first source | aromatic ether; aromatic ketone; bromobenzenes; monofluorobenzenes; olefinic compound; tertiary amino compound | antineoplastic agent; EC 5.4.99.7 (lanosterol synthase) inhibitor |
| dodecyldimethylamine oxide | dodecyldimethylamine N-oxide : A tertiary amine oxide resulting from the formal oxidation of the amino group of dodecyldimethylamine. dodecyldimethylamine oxide: zwitterionic detergent | tertiary amine oxide | detergent; plant metabolite |