Target type: molecularfunction
Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue. [EC:3.5.1.52]
Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity refers to the catalytic ability of an enzyme to cleave the N-glycosidic bond between the asparagine residue of a protein and the N-acetylglucosamine moiety of an N-linked glycan. This process is essential for the maturation and proper folding of glycoproteins. The enzyme specifically recognizes and hydrolyzes the linkage between the amide group of asparagine and the N-acetylglucosamine sugar, releasing the glycan from the protein. This activity is crucial for various cellular processes, including protein trafficking, signaling, and cell-cell interactions.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase | A peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96IV0] | Homo sapiens (human) |
| Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase | A peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96IV0] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| batyl alcohol | batilol : An alkylglycerol that is glycerol in which one of the primary hydroxy groups has been converted into the corresponding octadecyl ether. It is used in cosmetics as a stabilising ingredient and skin-conditioning agent. batyl alcohol: RN given refers to cpd without isomeric designation | alkylglycerol | |
| castanospermine | castanospermine : A tetrahydroxyindolizidine alkaloid that consists of octahydroindolizine having four hydroxy substituents located at positions 1, 6, 7 and 8 (the 1S,6S,7R,8R,8aR-diastereomer). castanospermine: indolizidine alkaloid from seeds of Australian legume, Castanospermum australe | indolizidine alkaloid | anti-HIV-1 agent; anti-inflammatory agent; EC 3.2.1.* (glycosidase) inhibitor; metabolite |
| dactinomycin | Dactinomycin: A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015) | actinomycin | mutagen |