Target type: cellularcomponent
A protein complex that negatively regulates apoptotic processes. In human, this anti-apoptotic complex is a homodimer of BIRC5 (survivin) and provides one survivin molecule to the chromosomal passenger complex (CPC). [GOC:bhm, PMID:10949038]
The survivin complex is a multi-protein complex involved in regulating cell division and preventing apoptosis. It is primarily localized within the cytoplasm and at the spindle poles during mitosis. The complex is composed of several key proteins, including survivin, which acts as a scaffold, and other proteins that interact with it to carry out its functions.
- **Survivin**: This protein is a member of the inhibitor of apoptosis protein (IAP) family and acts as a key component of the complex. It interacts with other proteins and plays a crucial role in promoting cell division and inhibiting apoptosis.
- **BIRC5**: This protein is the gene that encodes survivin. It is highly expressed in proliferating cells and its expression is downregulated in differentiated cells.
- **Aurora B kinase**: This protein is a serine/threonine kinase that is essential for chromosome segregation and cytokinesis. It associates with survivin and other proteins in the complex to regulate spindle assembly and chromosome alignment during mitosis.
- **INCENP**: This protein is a chromosomal passenger protein that acts as a scaffold for the Aurora B kinase. It helps to target Aurora B kinase to the centromere and other mitotic structures.
- **Borealin**: This protein is a component of the chromosomal passenger complex, which is a multi-protein complex that regulates chromosome segregation and cytokinesis.
The survivin complex plays a crucial role in regulating cell division. It interacts with various components of the mitotic machinery to ensure proper chromosome segregation and cytokinesis. The complex also plays a role in preventing apoptosis, thereby promoting cell survival and proliferation. Its localization at the spindle poles during mitosis is essential for its function in regulating chromosome segregation and cytokinesis. The complex is a target for cancer therapy, as its overexpression is associated with tumorigenesis and resistance to chemotherapy.
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| Protein | Definition | Taxonomy |
|---|---|---|
| Baculoviral IAP repeat-containing protein 5 | A baculoviral IAP repeat-containing protein 5 that is encoded in the genome of human. [PMID:12719470, PMID:15917996, PMID:20929775, PRO:KER] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| benziodarone | benziodarone: minor descriptor (75-89); on-line & INDEX MEDICUS search BENZOFURANS (68-89) & IODOBENZOATES (74) | aromatic ketone | |
| 3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)-2-pyridone | 3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)-2-pyridone : A member of the class of pyridones that is 2-pyridone carrying cyano, phenyl and 3-bromo-6-hydroxyphenyl substituents at positions 3, 4 and 6 respectively | bromophenol; nitrile; pyridone |