Cry-Per complex

Definition

Target type: cellularcomponent

Nuclear transcriptional repressor complex that is capable of negatively regulating CLOCK-BMAL-dependent transactivation of genes in a delayed negative feedback manner which generates circadian rhythms. [GOC:bhm, PMID:24855952]

The Cry-Per complex is a protein complex that plays a crucial role in regulating circadian rhythms in animals. The cellular component of this complex is primarily located in the cytoplasm of cells, specifically within the **nucleus**. This localization is essential for its function as it interacts with DNA to regulate gene expression.

The Cry-Per complex is formed by the interaction of two proteins: **Cryptochrome (Cry)** and **Period (Per).** These proteins are expressed in a cyclical manner throughout the day, with their levels peaking at different times.

Within the nucleus, the Cry-Per complex interacts with other proteins, including **Clock (Clk)** and **Bmal1 (Brain and Muscle Arnt-like 1),** to form a transcriptional-translational feedback loop. This loop regulates the expression of genes involved in circadian rhythms, ensuring the precise timing of physiological processes throughout the day.

Specifically, the Cry-Per complex acts as a **transcriptional repressor** by binding to the promoter regions of genes involved in circadian rhythms, inhibiting their transcription. This repression is crucial for resetting the circadian clock and maintaining its rhythmicity.

In summary, the cellular component of the Cry-Per complex is primarily found within the nucleus of cells, where it interacts with other proteins to regulate gene expression and maintain circadian rhythms.'
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Proteins (2)

Compounds (1)