Target type: cellularcomponent
A protein complex which is capable of ATPase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:9606181]
ATPase complexes are intricate molecular machines that harness the energy released from ATP hydrolysis to perform essential cellular functions. They are composed of multiple protein subunits, each with specific roles in the catalytic cycle. These subunits assemble into distinct structural domains, facilitating the binding and hydrolysis of ATP, as well as the transduction of energy to drive various cellular processes.
The core of an ATPase complex is often a catalytic domain containing the active site where ATP is hydrolyzed. This domain typically exhibits conserved structural motifs, including Walker A and Walker B motifs, which are crucial for ATP binding and hydrolysis.
Flanking the catalytic domain are other domains that contribute to the complex's overall function. These may include domains for substrate binding, transmembrane transport, or interaction with other cellular components. The arrangement of these domains can vary widely depending on the specific type of ATPase complex.
In addition to protein subunits, some ATPase complexes may also associate with non-protein components, such as lipids or metal ions. These components can play essential roles in stabilizing the complex, regulating its activity, or facilitating its interactions with other molecules.
Overall, the cellular component of an ATPase complex is a dynamic and multifaceted structure, with a highly organized arrangement of protein subunits and possibly other components. This complex architecture enables the ATPase complex to efficiently convert the chemical energy stored in ATP into mechanical work, driving a wide range of cellular processes, from muscle contraction to DNA replication.'
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Protein | Definition | Taxonomy |
---|---|---|
Histone-binding protein RBBP7 | A histone-binding protein RBBP7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16576] | Homo sapiens (human) |
Serine/threonine-protein phosphatase 2A activator | A serine/threonine-protein phosphatase 2A regulatory subunit B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15257] | Homo sapiens (human) |
Nucleosome-remodeling factor subunit BPTF | A nucleosome-remodeling factor subunit BPTF that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q12830] | Homo sapiens (human) |
Histone-binding protein RBBP4 | A histone-binding protein RBBP4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q09028] | Homo sapiens (human) |
Transitional endoplasmic reticulum ATPase | A transitional endoplasmic reticulum ATPase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P55072] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
---|---|---|---|
clotrimazole | conazole antifungal drug; imidazole antifungal drug; imidazoles; monochlorobenzenes | antiinfective agent; environmental contaminant; xenobiotic | |
przewaquinone d | przewaquinone D: isolated from root of Salvia przewalskii; structure given in first source; RN given refers to the trans- isomer, przewaquinone D | ||
Tautomycin | carboxylic ester | ||
Methylenedioxycinnamic acid | hydroxycinnamic acid | ||
3,4-methylenedioxy-beta-nitrostyrene | 3,4-methylenedioxy-beta-nitrostyrene: tyrosine kinase inhibitor that prevents platelet glycoprotein IIb/IIIa activation; structure in first source | ||
4-(4-(4-chloro-phenyl)thiazol-2-ylamino)phenol | substituted aniline | ||
bi 2536 | |||
au-1 | |||
ML240 | ML240 : A member of the class of quinazolines that is quinazoline which is substituted at positions 2, 5 and 8 by 2-amino-1H-benzimidazol-1-yl, benzylnitrilo and methoxy groups, respectively. It is a ATP-competetive inhibitor of AAA ATPase p97, also known as valosin-containing protein (VCP). | aromatic amine; aromatic ether; benzimidazoles; primary amino compound; quinazolines; secondary amino compound | antineoplastic agent |
i-bet726 | |||
epz-6438 | tazemetostat: a histone methyltransferase EZH2 inhibitor with antineoplastic activity | ||
gsk343 | GSK343 : A member of the class of indazoles that is 1-isopropyl-1H-indazole-4-carboxamide in which the nitrogen of the carboxamide group is substituted by a (6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl group and in which the indazole ring is substituted at position 6 by a 2-(4-methylpiperazin-1-yl)pyridin-4-yl group. A highly potent and selective EZH2 inhibitor (IC50 = 4 nM). GSK343: an EZH2 methyltransferase inhibitor | aminopyridine; indazoles; N-alkylpiperazine; N-arylpiperazine; pyridone; secondary carboxamide | antineoplastic agent; apoptosis inducer; EC 2.1.1.43 (enhancer of zeste homolog 2) inhibitor |
ganciclovir | 2-aminopurines; oxopurine | antiinfective agent; antiviral drug |