Target type: cellularcomponent
A ciliary basal body that is part of a kinocilium. [GO_REF:0000064, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:15855039, PMID:15882574]
The kinociliary basal body is a specialized microtubule-based structure that anchors the kinocilium, a hair-like projection found in sensory cells of the inner ear and other sensory organs. It is a complex structure comprised of several key components:
* **Microtubule triplets:** The basal body is composed of nine microtubule triplets arranged in a ring, forming the core of the structure. These triplets are interconnected by various proteins and serve as the foundation for the kinocilium.
* **Transitional fibers:** These fibers connect the basal body to the plasma membrane and are involved in anchoring the kinocilium and guiding its assembly.
* **Y-shaped linkers:** These structures connect the microtubule triplets and are responsible for maintaining the overall structure and stability of the basal body.
* **Ciliary necklace:** A ring of proteins surrounding the basal body, which helps regulate the transport of proteins into the kinocilium.
* **Centriole-associated proteins:** Various proteins associated with the basal body contribute to its assembly, function, and stability.
The kinociliary basal body plays a crucial role in sensory transduction by anchoring the kinocilium and providing a platform for its assembly. It is a dynamic structure that undergoes regulated changes in response to sensory stimuli, allowing for the fine-tuning of sensory perception.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Dual specificity protein phosphatase CDC14A | A dual specificity protein phosphatase CDC14A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UNH5] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| cefsulodin | cefsulodin : A pyridinium-substituted semi-synthetic, broad-spectrum, cephalosporin antibiotic. Cefsulodin: A pyridinium-substituted semisynthetic, broad-spectrum antibacterial used especially for Pseudomonas infections in debilitated patients. | cephalosporin; organosulfonic acid; primary carboxamide | antibacterial drug |
| 3-(1-(3-(biphenyl-4-ylamino)-3-oxopropyl)-1h-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1h-indole-5-carboxylic acid | 3-(1-(3-(biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid: an SHP2 inhibitor; structure in first source |