Target type: cellularcomponent
A SWI/SNF subcomplex that incorporates two mutually exclusive paralogs, GLTSCR1 (glioma tumor suppressor candidate region gene 1) or GLTSCR1L (GLTSCR1-like), BRD9 (bromodomain-containing 9) and the BAF subunits BAF155, BAF60, SS18, BAF53a, and BRG1/BRM. [PMID:29374058]
The GBAF complex, also known as the GATA-binding factor complex, is a multi-protein complex that plays a crucial role in gene regulation. It is involved in the regulation of various cellular processes, including hematopoiesis, development, and immunity. The cellular component of the GBAF complex is primarily localized in the nucleus, where it associates with DNA and other nuclear factors. The complex comprises several key proteins: \\n
* **GATA-binding factors (GATA1, GATA2, and GATA3):** These are transcription factors that bind to specific DNA sequences called GATA motifs. They act as the core components of the GBAF complex, providing the DNA-binding activity. \\n
* **Friend of GATA (FOG) proteins (FOG1 and FOG2):** These proteins interact with GATA factors and play a crucial role in modulating their activity. They act as co-repressors or co-activators depending on the cellular context and the specific GATA factor involved. FOG proteins can also interact with other nuclear proteins, expanding the regulatory network of the GBAF complex. \\n
* **Other associated proteins:** Additional proteins can associate with the GBAF complex, depending on the cellular context and the specific function being regulated. These can include chromatin remodelers, histone modifiers, and other transcription factors. The GBAF complex assembles dynamically, with the specific composition varying depending on the cell type and the developmental stage. This dynamic assembly allows the complex to respond to different signals and regulate diverse gene expression programs. The precise role of the GBAF complex in gene regulation depends on the specific GATA factor involved, the cellular context, and the other proteins associated with the complex.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Bromodomain-containing protein 9 | A bromodomain-containing protein 9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H8M2] | Homo sapiens (human) |
| Transcription activator BRG1 | A transcription activator BRG1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51532] | Homo sapiens (human) |
| Probable global transcription activator SNF2L2 | A probable global transcription activator SNF2L2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51531] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| ferrocin c | N-methyl-2-quinolone: structure in first source | ||
| tg 003 | TG 003: a Clk inhibitor; structure in first source | ||
| su 11248 | monocarboxylic acid amide; pyrroles | angiogenesis inhibitor; antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; immunomodulator; neuroprotective agent; vascular endothelial growth factor receptor antagonist | |
| i-bet726 | |||
| pf-06687252 | PF-06687252: a SMARCA2/4 bromodomain inhibitor; structure in first source PFI-3 : An azabicycloalkane that is (1R,4R)-2,5-diazabicyclo[2.2.1]heptane which is substituted at position 2 by a 3-(2-hydroxyphenyl)-3-oxoprop-1-en-1-yl group and at position 5 by a pyridin-2-yl group. It is a potent and selective inhibitor of polybromo 1 (Kd = 48 nM), SMARCA2 and SMARCA4 (Kd = 89 nM) bromodomains. | azabicycloalkane; enone; phenols; pyridines | |
| pf-477736 | PF 00477736: a Chk1 inhibitor; structure in first source PF-00477736 : A diazepinoindole that is 8-amino-4,5-dihydro-6H-[1,2]diazepino[4,5,6-cd]indol-6-one which is substituted at position 2 by a 1-methylpyrazol-4-yl group and in which the amino group at position 8 has undergone condensation with the carboxy group of (2R)-2-cyclohexylglycine to give the corresponding carboxamide. It is an inhibitor of checkpoint kinase 1 (Chk 1). |