HCN channel complex

Definition

Target type: cellularcomponent

A cation ion channel with a preference for K+ over Na+ ions, which is activated by membrane hyperpolarization, and consists of a tetramer of HCN family members. Some members of this family (HCN1, HCN2 and HCN4) are also activated when cAMP binds to their cyclic nucleotide binding domain (CNBD). Channel complexes of this family play an important role in the control of pacemaker activity in the heart. [PMID:20829353]

The HCN channel complex is a transmembrane protein complex that mediates the flow of sodium and potassium ions across the plasma membrane of neurons and other excitable cells. The complex is composed of four subunits, each of which contains six transmembrane domains. The subunits are arranged in a tetrameric structure, with each subunit contributing to the formation of the ion pore. The HCN channel complex is localized to the plasma membrane and is thought to play a role in regulating neuronal excitability, pacemaker activity, and synaptic plasticity. The cellular component of the HCN channel complex includes the plasma membrane, which is the outer boundary of the cell, and the cytoplasm, which is the fluid that fills the cell. The HCN channel complex is anchored to the plasma membrane by a hydrophobic transmembrane domain, and the cytoplasmic domains interact with a variety of intracellular signaling molecules. This interaction with signaling molecules allows the HCN channel complex to be regulated by a variety of factors, including neurotransmitters, hormones, and second messengers.'
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Proteins (1)

Compounds (2)