Target type: cellularcomponent
The region of the presynaptic membrane that is part of the presynaptic endocytic zone - where synaptic vesicles are endocytosed and recycled following release. [GOC:dos]
The presynaptic endocytic zone membrane is a specialized region of the presynaptic plasma membrane that plays a critical role in the recycling of synaptic vesicles. This region is characterized by its high concentration of proteins involved in endocytosis, including clathrin, adaptor proteins, and dynamin. The endocytic zone membrane is also enriched in lipids, such as phosphatidylinositol 4,5-bisphosphate (PIP2), which is involved in the recruitment of endocytic proteins.
The endocytic zone membrane is highly dynamic and constantly undergoes cycles of endocytosis and exocytosis. During endocytosis, synaptic vesicles are internalized from the presynaptic plasma membrane and transported to the cytoplasm, where they are recycled and refilled with neurotransmitter. During exocytosis, synaptic vesicles fuse with the presynaptic plasma membrane and release their neurotransmitter into the synaptic cleft.
The endocytic zone membrane is a complex and dynamic structure that is essential for the proper functioning of synapses. The proteins and lipids that make up this membrane are precisely organized and regulated to ensure efficient and accurate neurotransmitter release and recycling.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Dynamin-1 | A dynamin-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q05193] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| cetrimonium bromide | cetyltrimethylammonium bromide : The organic bromide salt that is the bromide salt of cetyltrimethylammonium; one of the components of the topical antiseptic cetrimide. | organic bromide salt; quaternary ammonium salt | detergent; surfactant |
| n,n-dimethyl-1-dodecanamine | N,N-dimethyl-1-dodecanamine: increases body weight & feed efficiency in animals; RN given refers to parent cpd | ||
| decylamine | decylamine: structure | alkylamine | |
| myristic acid | Myristic Acid: A saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils. It is used to synthesize flavor and as an ingredient in soaps and cosmetics. (From Dorland, 28th ed) tetradecanoate : A long-chain fatty acid anion that is the conjugate base of myristic acid; major species at pH 7.3. tetradecanoic acid : A straight-chain, fourteen-carbon, long-chain saturated fatty acid mostly found in milk fat. | long-chain fatty acid; straight-chain saturated fatty acid | algal metabolite; Daphnia magna metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; human metabolite |
| dodecylamine | dodecylamine: RN given refers to parent cpd | primary aliphatic amine | |
| dodecyltrimethylammonium bromide | dodecyltrimethylammonium bromide : A quarternary ammonium cation having one dodecyl and three methyl substituents around the central nitrogen. | bromide salt; quaternary ammonium salt | surfactant |
| stearylamine | octadecan-1-amine : An 18-carbon primary aliphatic amine. stearylamine: RN given refers to parent cpd | primary aliphatic amine | film-forming compound |
| n-tetradecylamine | N-tetradecylamine: RN given refers to parent cpd | alkylamine | |
| 1,12-dodecamethylenediamine | 1,12-dodecamethylenediamine: RN given refers to parent cpd dodecane-1,12-diamine : An alkane-alpha,omega-diamine that is dodecane substituted by amino groups at positions 1 and 12. | alkane-alpha,omega-diamine | |
| stearyltrimethylammonium bromide | octadecyltrimethylammonium bromide: structure in first source | ||
| ag-213 | tyrphostin 47: inhibits protein-tyrosine kinase activity of EGF-R both in vitro and in living cells; | ||
| ag 99 | tyrphostin A46: epidermal growth factor-urogastrone receptor antagonist | ||
| dynole 34-2 | dynole 34-2: a dynamin inhibitor; structure in first source | ||
| n'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthahydrazide | catechols; hydrazide; hydrazone; naphthols | EC 3.6.5.5 (dynamin GTPase) inhibitor |