epidermal lamellar body

Definition

Target type: cellularcomponent

A specialized secretory organelle found in keratinocytes and involved in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function. [GOC:cjm, Wikipedia:Lamellar_granule]

Epidermal lamellar bodies, also known as Odland bodies, are complex, membrane-bound organelles found in the granular layer of the epidermis. These organelles play a crucial role in maintaining the skin's barrier function by releasing lipids that form the intercellular cement between corneocytes. The lamellar body is a dynamic structure composed of a variety of components:

- **Lipid bilayer membranes:** These form the core structure of the lamellar body, creating a series of concentric lamellae.
- **Lipid molecules:** The lamellar body is enriched in various lipid molecules, including ceramides, cholesterol, and fatty acids. These lipids are organized into multilamellar structures, creating a highly hydrophobic barrier.
- **Enzymes:** Enzymes such as ceramidase and phospholipase are present within the lamellar body. These enzymes help to modify the lipid composition, ensuring the proper formation and function of the skin barrier.
- **Proteins:** Various proteins are associated with the lamellar body, including involucrin, loricrin, and filaggrin. These proteins contribute to the structural integrity of the lamellar body and its interaction with the surrounding keratinocytes.
- **Other components:** In addition to the above, lamellar bodies may contain other components such as glycosaminoglycans and small amounts of water.

The intricate composition and organization of lamellar bodies enable them to release their contents into the intercellular spaces, forming a protective lipid barrier that is essential for skin hydration, elasticity, and protection against environmental insults.'
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Proteins (2)

Compounds (4)