BRCA1-B complex

Definition

Target type: cellularcomponent

A protein complex that contains the BRCA1-BARD1 heterodimer, BACH1 and TopBP1, and binds to DNA during S phase at DNA damage sites. [GOC:mah, PMID:16391231]

The BRCA1-B complex is a multi-protein complex involved in DNA repair, specifically homologous recombination, which is crucial for maintaining genomic integrity. It functions as a scaffold, bringing together various proteins required for DNA repair at sites of DNA damage. The core components of this complex include the tumor suppressor protein BRCA1, which acts as the central hub, and the PALB2 protein, which interacts with BRCA1 and helps stabilize the complex.

The BRCA1-B complex is found in the nucleus, particularly at sites of DNA damage, where it plays a crucial role in the repair process. It recruits various other proteins, such as RAD51, RAD52, and the MRE11-RAD50-NBS1 (MRN) complex, which are all essential for the homologous recombination pathway. These proteins are recruited through various protein-protein interactions with BRCA1 and PALB2.

The complex is dynamic and undergoes conformational changes during the repair process. These changes are regulated by post-translational modifications, including phosphorylation, acetylation, and ubiquitination, which further fine-tune the complex's activity.

The BRCA1-B complex is essential for maintaining genomic stability, and its dysfunction is associated with an increased risk of cancer, particularly breast and ovarian cancers. Mutations in BRCA1 and PALB2 genes are commonly found in patients with these cancers, highlighting the critical role of this complex in DNA repair and cancer prevention.'
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Proteins (3)

Compounds (2)