BRCA1-A complex
Definition
Target type: cellularcomponent
A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites. [GOC:mah, PMID:19261749]
The BRCA1-A complex is a multiprotein complex involved in DNA damage repair and cell cycle regulation. Its cellular component is characterized by its localization within the nucleus and its association with chromatin. The complex consists of the BRCA1 protein, which acts as a scaffold, and several other proteins that bind to BRCA1 and contribute to the complex's function. These proteins include: \\n\\n- **PALB2**: PALB2 interacts directly with BRCA1 and is essential for the recruitment of BRCA2 to the complex. It also plays a role in stabilizing the complex and promoting its interaction with DNA. \\n\\n- **BRCA2**: BRCA2 is a large protein involved in homologous recombination repair, a crucial pathway for repairing double-strand DNA breaks. BRCA2 interacts with RAD51, a protein that promotes strand invasion and DNA recombination. \\n\\n- **RAD51**: RAD51 is a DNA-binding protein that forms nucleoprotein filaments on single-stranded DNA. These filaments facilitate the search for homologous sequences on undamaged DNA and promote strand exchange, leading to the repair of the damaged DNA. \\n\\n- **Other proteins**: Other proteins known to associate with the BRCA1-A complex include: \\n - **MRE11**, **RAD50**, and **NBS1**: These proteins form a complex known as the MRN complex, which is involved in DNA double-strand break recognition and processing. \\n - **CTIP**: This protein promotes the recruitment of BRCA1 to DNA damage sites and helps to initiate DNA repair. \\n - **BACH1**: This protein is involved in the regulation of DNA damage response. \\n\\nThe BRCA1-A complex is dynamic and its composition may vary depending on the specific DNA damage and cellular context. This dynamic nature allows the complex to adapt to different repair needs and ensures efficient DNA repair. The complex's localization within the nucleus ensures its proximity to the DNA damage sites and its association with chromatin facilitates its access to damaged DNA.'
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Proteins (2)
| Protein | Definition | Taxonomy |
|---|---|---|
| BRCA1-associated RING domain protein 1 | A BRCA1-associated RING domain protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99728] | Homo sapiens (human) |
| Breast cancer type 1 susceptibility protein | A breast cancer type 1 susceptibility protein that is encoded in the genome of human. [PRO:DNx] | Homo sapiens (human) |
Compounds (1)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| beta-thujaplicin | beta-thujaplicin : A monoterpenoid that is cyclohepta-2,4,6-trien-1-one substituted by a hydroxy group at position 2 and an isopropyl group at position 4. Isolated from Thuja plicata and Chamaecyparis obtusa, it exhibits antimicrobial activities. beta-thujaplicin: structure | cyclic ketone; enol; monoterpenoid | antibacterial agent; antifungal agent; antineoplastic agent; antiplasmodial drug; plant metabolite |