ERCC4-ERCC1 complex

Definition

Target type: cellularcomponent

A heterodimeric nucleotide-excision repair complex that has endonuclease activity specific for bubble structures characteristic of certain DNA lesions. The subunits are known as XPF/ERCC4 and ERCC1 in mammals, and Rad1p and Rad10p in S. cerevisiae. [PMID:14734547]

The ERCC4-ERCC1 complex is a critical DNA repair enzyme involved in nucleotide excision repair (NER). It is a heterodimer composed of two subunits: ERCC4 (also known as XPF) and ERCC1. This complex functions as a 5' to 3' DNA endonuclease, specifically recognizing and cleaving the damaged DNA strand 5' to the lesion. The complex is localized to the nucleus and is primarily found in the nucleoplasm and associated with chromatin. The ERCC4-ERCC1 complex interacts with other NER factors, including XPA, RPA, and the TFIIH complex, to initiate and execute the NER pathway. In the context of the cellular component, the ERCC4-ERCC1 complex is primarily associated with the **nuclear matrix**, a structural framework within the nucleus that provides support and organization for the DNA and other nuclear components. This association allows the complex to efficiently access damaged DNA and perform its repair function. It may also interact with other nuclear structures, such as the **nucleolus**, where ribosome biogenesis occurs, and the **nuclear envelope**, the membrane that surrounds the nucleus. Ultimately, the cellular localization of the ERCC4-ERCC1 complex is crucial for its role in maintaining genome integrity and preventing mutations.'
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Proteins (2)

Compounds (2)