Target type: cellularcomponent
A complex of three proteins, which in animals is approximately 150kDa and consists of the insulin-like growth factor (IGF), the insulin-like growth factor binding protein-3 (IGFBP-3), or -5 (IGFBP-5) and an acid-labile subunit (ALS). The complex plays a role in growth and development. [GOC:jl, PMID:12239079]
The insulin-like growth factor (IGF) ternary complex is a molecular assembly that plays a crucial role in the regulation of cell growth, differentiation, and metabolism. This complex comprises three components: IGF-I or IGF-II, an IGF-binding protein (IGFBP), and an acid-labile subunit (ALS). The cellular component of this complex is a dynamic entity, localized primarily to the extracellular matrix (ECM), but also found in association with cell membranes and within specific intracellular compartments.
The ECM localization of the IGF ternary complex is essential for its function. The IGFBPs bind to IGFs with high affinity, preventing their premature degradation and extending their half-life. However, IGFBPs also act as chaperones, delivering IGFs to their target receptors. This delivery process is facilitated by the ALS, which forms a stable complex with IGFBPs and IGFs, forming a large multimeric structure that is retained within the ECM.
The IGF ternary complex is associated with cell membranes through interactions with specific cell surface receptors. These interactions are crucial for signaling pathways that regulate cell growth, differentiation, and survival. While the majority of the IGF ternary complex remains in the ECM, a fraction can be internalized via endocytosis, where it may be trafficked to specific intracellular compartments. This intracellular localization is likely involved in regulating the availability of IGFs for intracellular signaling events.
The cellular component of the IGF ternary complex is thus not a static entity but a dynamic structure that continuously interacts with the ECM, cell membranes, and intracellular compartments. These interactions are crucial for the complex's role in regulating cellular processes, and disruption of these interactions can contribute to a range of pathological conditions.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Insulin-like growth factor-binding protein 5 | An insulin-like growth factor-binding protein 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P24593] | Homo sapiens (human) |
| Insulin-like growth factor-binding protein 3 | An insulin-like growth factor-binding protein 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P17936] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| dimethyl sulfoxide | dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents. Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation. | sulfoxide; volatile organic compound | alkylating agent; antidote; Escherichia coli metabolite; geroprotector; MRI contrast agent; non-narcotic analgesic; polar aprotic solvent; radical scavenger |
| npc 15199 | leucine derivative | ||
| nbi 31772 | NBI 31772: an insulin-like growth factor-binding protein ligand; structure in first source NBI-31772 : An isoquinoline substituted by 3,4-dihydroxybenzoyl, carboxy, hydroxy, and hydroxy groups at positions 1, 3, 6, and 7, respectively. It is a potent inhibitor of insulin-like growth factor-1 binding protein (IGFBP). | aromatic ketone; benzenediols; hydroxy monocarboxylic acid; isoquinolines; tetrol | insulin-like growth factor-binding protein inhibitor |