PR-DUB complex

Definition

Target type: cellularcomponent

A multimeric protein complex that removes monoubiquitin from histone H2A. In Drosophila and mammals, the core of the complex is composed of Calypso/BAP1 and Asx/ASXL1, respectively. [PMID:20436459]

The PR-DUB complex is a cellular machinery involved in the ubiquitin-proteasome system, a crucial pathway for protein degradation. It comprises several key components:
* **Proteasome Regulatory Particle (RP):** The RP is a multi-subunit complex that recognizes and binds to ubiquitinated proteins, marking them for degradation. It consists of two subcomplexes, the 19S regulatory particle and the 20S core particle.
* **Deubiquitinases (DUBs):** These enzymes are responsible for removing ubiquitin chains from target proteins, thereby regulating their stability and function. The PR-DUB complex contains specific DUBs, such as USP14 and Rpn11, which are critical for proteasome activity.
* **Ubiquitin-binding proteins:** These proteins, such as Rpn10 and Rpn13, bind to ubiquitinated proteins and facilitate their delivery to the proteasome.

The precise arrangement of these components within the PR-DUB complex is complex. However, a key feature is the close proximity of the DUBs to the proteasome core particle, allowing for efficient ubiquitin removal and degradation. The PR-DUB complex is dynamic and can undergo conformational changes to interact with various ubiquitinated substrates. This dynamic behavior allows for fine-tuning of protein degradation and cellular processes.'
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Proteins (1)

Compounds (3)