Ubiquitin carboxyl-terminal hydrolase BAP1

A ubiquitin carboxyl-terminal hydrolase BAP1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92560]

Synonyms

EC 3.4.19.12;
BRCA1-associated protein 1;
Cerebral protein 6

Research

Bioassay Publications (0)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0)	18.7374
1990's	0 (0)	18.2507
2000's	0 (0)	29.6817
2010's	0 (0)	24.3611
2020's	0 (0)	2.80

Compounds (3)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)
5-(1,3-benzodioxol-5-yl)-N-(2-furanylmethyl)-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinecarboxamide	Homo sapiens (human)	IC50	24.1687	3
N-[2-(4-acetyl-1-piperazinyl)phenyl]-2-(5-methyl-2-propan-2-ylphenoxy)acetamide	Homo sapiens (human)	IC50	36.7435	1
4-[[2-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)thio]-1-oxoethyl]amino]benzoic acid ethyl ester	Homo sapiens (human)	IC50	23.3297	1

Enables

This protein enables 6 target(s):

Target	Category	Definition
chromatin binding	molecular function	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130]
cysteine-type deubiquitinase activity	molecular function	An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. [GOC:jh2, PMID:30783221]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
peptidase activity	molecular function	Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. [GOC:jl, ISBN:0815332181]
chromatin DNA binding	molecular function	Binding to DNA that is assembled into chromatin. [GOC:mah]
histone H2A deubiquitinase activity	molecular function	A histone deubiquitinase that cleaves ubiquitin from a histone H2A protein to which it is conjugated. [PMID:18226187, PMID:20436459]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
PR-DUB complex	cellular component	A multimeric protein complex that removes monoubiquitin from histone H2A. In Drosophila and mammals, the core of the complex is composed of Calypso/BAP1 and Asx/ASXL1, respectively. [PMID:20436459]

Involved In

This protein is involved in 29 target(s):

Target	Category	Definition
mitotic cell cycle	biological process	Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. [GOC:mah, ISBN:0815316194, Reactome:69278]
regulation of cell growth	biological process	Any process that modulates the frequency, rate, extent or direction of cell growth. [GOC:go_curators]
in utero embryonic development	biological process	The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. [GOC:go_curators, GOC:mtg_sensu]
tissue homeostasis	biological process	A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function. [GOC:add, GOC:isa_complete]
thrombocyte differentiation	biological process	The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis. [GOC:add]
chromatin remodeling	biological process	A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]
ubiquitin-dependent protein catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. [GOC:go_curators]
negative regulation of cell population proliferation	biological process	Any process that stops, prevents or reduces the rate or extent of cell proliferation. [GOC:go_curators]
response to inorganic substance	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. [GOC:sm]
gene expression	biological process	The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes. [GOC:txnOH-2018, PMID:25934543, PMID:31580950]
protein deubiquitination	biological process	The removal of one or more ubiquitin groups from a protein. [GOC:ai]
neutrophil differentiation	biological process	The process in which a myeloid precursor cell acquires the specialized features of a neutrophil. [GOC:mah]
myeloid cell apoptotic process	biological process	Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage. [CL:0000763, GOC:add, GOC:mtg_apoptosis, PMID:11292031, PMID:15330259, PMID:17133093]
monoubiquitinated protein deubiquitination	biological process	The removal of the ubiquitin group from a monoubiquitinated protein. [GOC:bf]
common myeloid progenitor cell proliferation	biological process	The multiplication or reproduction of common myeloid progenitor cells, resulting in the expansion of a cell population. A common myeloid progenitor cell is a progenitor cell committed to the myeloid lineage. [CL:0000049, GOC:BHF]
protein modification process	biological process	The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). [GOC:bf, GOC:jl]
platelet morphogenesis	biological process	Generation and organization of a platelet, a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation. [CL:0000233, GOC:BHF, GOC:vk]
erythrocyte maturation	biological process	A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state. [GOC:devbiol, GOC:jl]
nucleate erythrocyte differentiation	biological process	The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds. [GOC:jl]
negative regulation of DNA-templated transcription	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
regulation of inflammatory response	biological process	Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. [GOC:ai]
regulation of cell cycle	biological process	Any process that modulates the rate or extent of progression through the cell cycle. [GOC:ai, GOC:dph, GOC:tb]
hematopoietic stem cell homeostasis	biological process	Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells. [GOC:dph, PMID:21508411]
macrophage homeostasis	biological process	The process of regulating the proliferation and elimination of macrophage cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. [GOC:dph, PMID:21727904]
neuron cellular homeostasis	biological process	The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state. [GOC:BHF, GOC:mah]
leukocyte proliferation	biological process	The expansion of a leukocyte population by cell division. [GOC:add]
protein K48-linked deubiquitination	biological process	A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein. [GOC:mah]
regulation of cytokine production involved in inflammatory response	biological process	Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response. [GOC:TermGenie]
positive regulation of protein targeting to mitochondrion	biological process	Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24270810]