Toll-like receptor 2-Toll-like receptor 6 protein complex

Definition

Target type: cellularcomponent

A heterodimeric protein complex containing Toll-like receptor 2 (TLR2) and Toll-like receptor 6 (TLR6). [GOC:add, GOC:signaling, PMID:19931471, PMID:21481769]

The Toll-like receptor 2-Toll-like receptor 6 (TLR2-TLR6) protein complex is a transmembrane receptor complex that recognizes a wide range of pathogen-associated molecular patterns (PAMPs), including diacylated lipopeptides, lipoproteins, and bacterial glycolipids. The complex is typically found on the cell surface, specifically on the plasma membrane. However, it can also be localized to intracellular compartments like endosomes and lysosomes.

The TLR2-TLR6 complex is composed of two subunits: TLR2 and TLR6. Both TLR2 and TLR6 are type I transmembrane proteins with an extracellular domain containing leucine-rich repeats (LRRs) and a cytoplasmic domain known as the Toll/IL-1 receptor (TIR) domain.

The extracellular domain of TLR2 and TLR6 interacts with PAMPs. TLR2 and TLR6 are known to form heterodimers, meaning they come together to form a functional unit. The TLR2-TLR6 heterodimer is thought to be the primary receptor for diacylated lipopeptides, such as those found in bacterial cell walls. This heterodimerization is crucial for the complex's ability to recognize and bind PAMPs.

Upon binding to a PAMP, the TLR2-TLR6 complex undergoes conformational changes. These changes initiate a cascade of intracellular signaling events, ultimately leading to the activation of transcription factors, such as NF-κB. NF-κB then translocates to the nucleus and activates the transcription of genes involved in the inflammatory response.

The cellular component of the TLR2-TLR6 complex can be summarized as follows:

* **Plasma membrane:** The complex is primarily found on the cell surface, where it encounters PAMPs from invading pathogens.
* **Endosomes and lysosomes:** The TLR2-TLR6 complex can also be localized to intracellular compartments like endosomes and lysosomes. This intracellular localization allows the complex to recognize and respond to PAMPs that are internalized by the cell.

In summary, the TLR2-TLR6 protein complex is a crucial component of the innate immune system, recognizing and responding to a variety of bacterial PAMPs through its localization on the cell surface and intracellular compartments.'
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Proteins (1)

Compounds (2)