brahma complex

Definition

Target type: cellularcomponent

A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the Drosophila brm (brahma) or mammalian SMARCA2/BAF190B/BRM gene, or an ortholog thereof. [GOC:bhm, PMID:10809665, PMID:12482982]

The Brahma complex, a key player in chromatin remodeling, is a multi-protein complex with a core structure comprising the ATPase Brahma (BRM or SMARCA2) or SMARCA4 (BRG1) proteins. These ATPases are essential for the complex's function, as they utilize ATP hydrolysis to alter the structure of nucleosomes, the fundamental units of chromatin. The Brahma complex also harbors a variety of other proteins, including BAF155, BAF170, BAF47, BAF53A/B, BAF60A/B/C, and BAF57. These proteins contribute to the complex's specificity and regulation, directing it to specific genomic locations and influencing its activity. This modular structure allows the Brahma complex to interact with diverse transcription factors and signaling pathways, orchestrating a wide array of cellular processes, including gene regulation, development, and DNA repair. Importantly, the composition of the Brahma complex can vary depending on the cell type and developmental stage, reflecting its diverse roles in cellular function. The cellular component of the Brahma complex is primarily located within the nucleus, where it associates with chromatin, interacting with nucleosomes and influencing the accessibility of DNA to regulatory proteins.'
"

Proteins (1)

Compounds (2)