transcription factor TFTC complex

Definition

Target type: cellularcomponent

A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity. [PMID:10373431, PMID:9603525]

The TFTC complex, also known as the transcription factor TFIIIC complex, is a multi-protein complex essential for transcription initiation in eukaryotes. It plays a crucial role in recognizing and binding to the DNA promoter region of genes, specifically at the TATA box and the B-block. The complex consists of several subunits, each with a distinct function in the overall process of transcription. These subunits include:

- **TFIIIC1 (or GTF3C1):** This subunit is responsible for DNA binding, specifically at the TATA box. It acts as a scaffold for other subunits of the complex.
- **TFIIIC2 (or GTF3C2):** This subunit is responsible for binding to the B-block, a DNA sequence located downstream of the TATA box. It also plays a role in recruiting RNA polymerase III.
- **TFIIIC3 (or GTF3C3):** This subunit is a zinc finger protein that binds to specific DNA sequences, contributing to the overall stability of the complex.
- **TFIIIC4 (or GTF3C4):** This subunit interacts with other transcription factors and helps to regulate the activity of the complex.
- **TFIIIC5 (or GTF3C5):** This subunit is also known as the TFIIIC beta subunit and is responsible for recruiting RNA polymerase III to the promoter.

Once the TFTC complex is assembled at the promoter, it recruits RNA polymerase III, the enzyme responsible for transcribing genes. The complex facilitates the formation of the pre-initiation complex (PIC), a multi-protein complex that is essential for the initiation of transcription.

In summary, the TFTC complex is a crucial component of the transcription machinery in eukaryotes, playing a key role in the recognition, binding, and recruitment of RNA polymerase III to gene promoters, ultimately leading to the initiation of gene transcription.'
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Proteins (1)

Compounds (2)