Target type: cellularcomponent
A complex containing a RecQ family helicase and a topoisomerase III homologue (a member of the topoisomerase type IA subfamily); may also include one or more additional proteins; conserved from E. coli to human. [GOC:bhm, GOC:krc, PMID:15889139]
The RecQ family helicase-topoisomerase III complex is a multi-protein complex involved in DNA repair and replication. It consists of a RecQ helicase, a topoisomerase III, and other associated proteins. The cellular component of this complex is primarily localized within the nucleus, where it plays a crucial role in resolving DNA structures that can obstruct replication or transcription. The complex functions by unwinding DNA duplexes using the helicase activity of its RecQ subunit, while the topoisomerase III subunit removes topological constraints by breaking and rejoining DNA strands. The associated proteins contribute to the stability and regulation of the complex. The exact composition of the complex can vary depending on the specific RecQ helicase involved and the organism being studied. However, the core components of the RecQ helicase and topoisomerase III are essential for its function in maintaining genomic integrity.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Bloom syndrome protein | A RecQ-like DNA helicase BLM that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54132] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| 1-(3,4-dichlorophenyl)-3-(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)urea | ureas | ||
| 1-[4-fluoro-3-(trifluoromethyl)phenyl]-3-(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)urea | ureas |