U2 snRNP
Definition
Target type: cellularcomponent
A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes. [GOC:krc, GOC:mah, ISBN:0879695897]
The U2 snRNP (small nuclear ribonucleoprotein) is a complex of proteins and RNA molecules that plays a crucial role in the splicing of pre-messenger RNA (pre-mRNA). The cellular component of U2 snRNP is a dynamic structure that undergoes significant conformational changes during the splicing process. It is localized in the nucleus, specifically within the spliceosome, a large RNA-protein complex that mediates the removal of introns from pre-mRNA. The U2 snRNP is composed of the U2 snRNA, which is a small nuclear RNA, and a set of associated proteins known as Sm proteins, Lsm proteins, and specific splicing factors. The U2 snRNA is a key component, as it recognizes the branch point sequence within introns, and forms a base-pairing interaction with it. The U2 snRNP also interacts with other snRNPs, namely U1, U4, U5, and U6, to form the active spliceosome. The Sm and Lsm proteins play a structural role in the U2 snRNP, contributing to its stability and ensuring proper interactions with other splicing factors. In summary, the cellular component of U2 snRNP is a complex and dynamic structure that plays a crucial role in the splicing process. Its key components include the U2 snRNA, Sm proteins, Lsm proteins, and specific splicing factors, which collectively ensure efficient and accurate splicing of pre-mRNA.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Splicing factor 3B subunit 3 | A splicing factor 3B subunit 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15393] | Homo sapiens (human) |
Compounds (4)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| trichostatin a | trichostatin A: chelates zinc ion in the active site of histone deacetylases, resulting in preventing histone unpacking so DNA is less available for transcription; do not confuse with TRICHOSANTHIN which is a protein; found in STREPTOMYCES | antibiotic antifungal agent; hydroxamic acid; trichostatin | bacterial metabolite; EC 3.5.1.98 (histone deacetylase) inhibitor; geroprotector |
| tacrolimus | tacrolimus (anhydrous) : A macrolide lactam containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus: A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro. | macrolide lactam | bacterial metabolite; immunosuppressive agent |
| lactacystin | lactam; S-substituted L-cysteine | ||
| e 7107 | E 7107: has antineoplastic activity |