Target type: cellularcomponent
A protein complex having ribose phosphate diphosphokinase activity. [GO:hjd, PMID:9348095]
The ribose phosphate diphosphokinase (PRPS) complex, a crucial enzyme in nucleotide biosynthesis, is a multi-protein complex localized within the cytoplasm of the cell. This complex is responsible for the phosphorylation of ribose 5-phosphate to 5-phosphoribosyl 1-pyrophosphate (PRPP), an essential precursor for the synthesis of purine and pyrimidine nucleotides. The PRPS complex is composed of two main components: PRPS1 and PRPS2, which catalyze the same reaction but differ in their kinetic properties and regulatory mechanisms. The PRPS1 enzyme is primarily found in the cytosol, while PRPS2 is localized in both the cytosol and the mitochondria. In addition to the catalytic subunits, the PRPS complex can also include other regulatory proteins, such as the enzyme phosphoribosylpyrophosphate synthetase (PRS). These regulatory proteins play an essential role in controlling the activity of the PRPS complex and maintaining the balance of nucleotide synthesis within the cell. Therefore, the cellular component of the ribose phosphate diphosphokinase complex is the cytoplasm and, potentially, the mitochondria, as it is a multi-protein complex that interacts with other proteins and enzymes to carry out its essential function.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Phosphoribosyl pyrophosphate synthase-associated protein 2 | A phosphoribosyl pyrophosphate synthase-associated protein 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60256] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| adefovir | adefovir : A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection. adefovir: inhibitor of African swine fever virus adefovir(1-) : A organophosphonate oxoanion obtained by removal of a proton from the phosphonate group of adefovir, a nucleoside reverse transcriptase inhibitor. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.). | 6-aminopurines; ether; phosphonic acids | antiviral drug; DNA synthesis inhibitor; drug metabolite; HIV-1 reverse transcriptase inhibitor; nephrotoxic agent |