Page last updated: 2024-10-24

mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)

Definition

Target type: cellularcomponent

The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled. [GOC:mtg_sensu, PMID:10838056]

The F(1) sector, also known as the catalytic sector, of mitochondrial proton-transporting ATP synthase is a complex molecular machine responsible for ATP synthesis. It is located on the matrix side of the inner mitochondrial membrane and consists of five distinct subunits: α, β, γ, δ, and ε. These subunits assemble into a hexagonal structure with three αβ dimers forming the catalytic core. Each αβ dimer contains a catalytic site where ATP is synthesized from ADP and inorganic phosphate. The γ subunit acts as a central stalk, connecting the F(1) sector to the F(o) sector, which is embedded in the inner mitochondrial membrane. The rotation of the γ subunit, driven by the proton gradient across the membrane, drives conformational changes in the αβ dimers, facilitating ATP synthesis. The δ and ε subunits play regulatory roles, modulating the activity of the F(1) sector. The F(1) sector is essential for cellular energy production, as it provides the majority of ATP required for cellular processes.'
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Proteins (1)

ProteinDefinitionTaxonomy
ATP synthase subunit epsilon, mitochondrialAn ATP synthase subunit epsilon, mitochondrial that is encoded in the genome of cow. [OMA:P05632, PRO:DAN]Bos taurus (cattle)

Compounds (5)

CompoundDefinitionClassesRoles
glyburideglyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.

Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
monochlorobenzenes;
N-sulfonylurea
anti-arrhythmia drug;
EC 2.7.1.33 (pantothenate kinase) inhibitor;
EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor;
hypoglycemic agent
n-cyano-n'-(1,1-dimethylpropyl)-n''-(3-pyridinyl)guanidineN-cyano-N'-(1,1-dimethylpropyl)-N''-(3-pyridinyl)guanidine: potassium channel openerpyridines
bms 180448BMS 180448: a potassium channel opener with cardioprotective and vasodilator properties; BMS-180426 is enantiomer with no antiischemic activity; structure in first source
cromakalim1-benzopyran
bms 191095BMS 191095: a mitochondrial K(ATP) opener; structure in first source