mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)

Definition

Target type: cellularcomponent

The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled. [GOC:mtg_sensu, PMID:10838056]

The F(1) sector, also known as the catalytic sector, of mitochondrial proton-transporting ATP synthase is a complex molecular machine responsible for ATP synthesis. It is located on the matrix side of the inner mitochondrial membrane and consists of five distinct subunits: α, β, γ, δ, and ε. These subunits assemble into a hexagonal structure with three αβ dimers forming the catalytic core. Each αβ dimer contains a catalytic site where ATP is synthesized from ADP and inorganic phosphate. The γ subunit acts as a central stalk, connecting the F(1) sector to the F(o) sector, which is embedded in the inner mitochondrial membrane. The rotation of the γ subunit, driven by the proton gradient across the membrane, drives conformational changes in the αβ dimers, facilitating ATP synthesis. The δ and ε subunits play regulatory roles, modulating the activity of the F(1) sector. The F(1) sector is essential for cellular energy production, as it provides the majority of ATP required for cellular processes.'
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Proteins (1)

Compounds (5)