Golgi cis cisterna

Definition

Target type: cellularcomponent

The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER. [ISBN:0815316194]

The cis Golgi cisterna is the first compartment of the Golgi apparatus, a complex organelle in eukaryotic cells responsible for processing and packaging proteins and lipids. It receives newly synthesized proteins and lipids from the endoplasmic reticulum (ER) through transport vesicles. The cis cisterna is characterized by a flattened, sac-like structure, often described as a "cistern." It is closely associated with the ER and is considered a transition zone between the ER and the rest of the Golgi apparatus. The cis Golgi cisterna contains a unique set of resident proteins, enzymes, and other molecules that perform specific functions, including:

- **Protein sorting and modification:** Proteins that arrive from the ER are sorted and further modified in the cis Golgi cisterna. This includes glycosylation (addition of sugar chains), phosphorylation (addition of phosphate groups), and other post-translational modifications.
- **Glycosylation:** The cis Golgi cisterna is a major site for the initiation of N-linked glycosylation, a process where sugar chains are added to asparagine residues of proteins. This type of glycosylation is important for protein folding, stability, and function.
- **Formation of transport vesicles:** The cis Golgi cisterna is involved in the formation of transport vesicles that carry proteins and lipids to the next compartment of the Golgi apparatus, the medial cisterna.

The cis Golgi cisterna is a dynamic structure that continuously receives material from the ER and buds off transport vesicles. Its composition and function are constantly changing in response to the needs of the cell.'
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Proteins (1)

Compounds (1)