nucleotide-excision repair factor 1 complex

Definition

Target type: cellularcomponent

One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively. [PMID:10915862]

The nucleotide-excision repair (NER) factor 1 complex is a multi-protein complex essential for the repair of DNA damage caused by UV light, chemical mutagens, and other agents. The complex is responsible for recognizing and removing damaged DNA segments, allowing for the synthesis of new, undamaged DNA. The cellular component of the NER factor 1 complex is localized to the nucleus, specifically within the nucleoplasm, and is associated with the chromatin. This localization allows the complex to interact with the DNA substrate and carry out its repair function. The complex consists of several subunits, each playing a specific role in the NER pathway. These subunits include: XPA, which recognizes damaged DNA and recruits other NER factors. RPA, which binds to single-stranded DNA and stabilizes the damaged region. XPF and ERCC1, which form a heterodimer that cuts the damaged DNA strand on the 5' side of the lesion. XPG, which cleaves the damaged DNA strand on the 3' side of the lesion. These subunits work together to initiate the repair process, identify the damaged segment, remove it, and facilitate the synthesis of new DNA. The NER factor 1 complex is crucial for maintaining genomic integrity and protecting cells from the detrimental effects of DNA damage.'
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Proteins (2)

Compounds (2)