negative regulation of metanephric comma-shaped body morphogenesis
Definition
Target type: biologicalprocess
Any process that stops, prevents, or reduces the frequency, rate or extent of metanephric comma-shaped body morphogenesis. [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
Negative regulation of metanephric comma-shaped body morphogenesis is a complex biological process that controls the development of the metanephric comma-shaped body, a crucial structure in kidney formation. This process involves a tightly regulated interplay of various signaling pathways, transcription factors, and cellular interactions. The metanephric comma-shaped body, also known as the nephric vesicle or cap mesenchyme, arises from the metanephric mesenchyme, a specialized population of cells that forms the nephron, the functional unit of the kidney.
The comma-shaped body undergoes a series of morphological transformations, including condensation, elongation, and invagination, eventually giving rise to the renal vesicle, the precursor of the nephron. During this process, precise control over cell proliferation, differentiation, and migration is essential for proper kidney development.
Negative regulation of metanephric comma-shaped body morphogenesis implies mechanisms that restrain or inhibit these developmental processes. These mechanisms can include:
* **Inhibition of signaling pathways:** Certain signaling pathways, such as the Wnt, FGF, and BMP pathways, are known to promote metanephric comma-shaped body formation. Negative regulation can occur through the suppression of these pathways, either by reducing the expression of their ligands, receptors, or downstream targets.
* **Expression of inhibitory factors:** Specific proteins can act as inhibitors of metanephric comma-shaped body morphogenesis. These factors may block the activity of signaling pathways, interfere with cell-cell interactions, or induce cell death.
* **Transcriptional regulation:** Transcription factors can regulate the expression of genes involved in metanephric comma-shaped body formation. Negative regulation can involve repressing the transcription of genes that promote the process or activating the transcription of genes that inhibit it.
* **Cellular interactions:** Negative regulation can also occur through cell-cell interactions. For example, specific cell types may release signals that inhibit the differentiation or proliferation of cells in the metanephric comma-shaped body.
Proper regulation of these negative processes is crucial to ensure that the metanephric comma-shaped body develops correctly and forms a functional kidney. Disruptions in these mechanisms can lead to congenital kidney malformations and other developmental abnormalities.
The specific molecular mechanisms underlying negative regulation of metanephric comma-shaped body morphogenesis are still being elucidated, but ongoing research provides valuable insights into the intricate developmental processes that govern kidney formation.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Bone morphogenetic protein 4 | A bone morphogenetic protein 4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P12644] | Homo sapiens (human) |
Compounds (3)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| dorsomorphin | dorsomorphin : A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling. dorsomorphin: an AMPK inhibitor | aromatic ether; piperidines; pyrazolopyrimidine; pyridines | bone morphogenetic protein receptor antagonist; EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} inhibitor |
| ldn 193189 | LDN 193189: inhibits bone morphogenetic protein signaling | pyrimidines | |
| ml347 | ML347: an ALK2 inhibitor; structure in first source |