negative regulation of metanephric S-shaped body morphogenesis
Definition
Target type: biologicalprocess
Any process that stops, prevents, or reduces the frequency, rate or extent of metanephric S-shaped body morphogenesis. [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
Negative regulation of metanephric S-shaped body morphogenesis is a complex biological process that ensures the proper formation and development of the kidney. The metanephric S-shaped body is a crucial structure during kidney development, acting as the precursor to the nephron, the functional unit of the kidney. This process involves a series of tightly regulated events, including cell signaling, transcription factors, and extracellular matrix interactions.
The S-shaped body undergoes a series of morphogenetic changes to form the mature nephron. These changes are driven by the coordinated activity of various signaling pathways, including the Wnt, FGF, and TGF-beta pathways. Negative regulation of this morphogenesis ensures that the S-shaped body develops at the correct rate and in the appropriate location within the kidney.
This negative regulation can be achieved through multiple mechanisms:
* **Inhibition of key signaling pathways:** Certain factors can inhibit the activity of the aforementioned signaling pathways, slowing down or halting the morphogenesis process. For example, antagonists of the Wnt or FGF pathways can prevent the activation of downstream targets necessary for S-shaped body development.
* **Regulation of transcription factors:** Transcription factors play a critical role in regulating gene expression during kidney development. Negative regulators can directly bind to DNA and block the transcription of genes involved in S-shaped body morphogenesis. This can lead to a decrease in the production of proteins necessary for the developmental process.
* **Modulation of extracellular matrix:** The extracellular matrix provides structural support and signaling cues during morphogenesis. Negative regulators can alter the composition or organization of the extracellular matrix, creating an environment that hinders S-shaped body development.
Dysregulation of negative regulation of metanephric S-shaped body morphogenesis can lead to congenital kidney defects, highlighting the importance of this tightly controlled process. This process ensures the proper formation of the nephron, ultimately leading to the development of a functional kidney.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Bone morphogenetic protein 4 | A bone morphogenetic protein 4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P12644] | Homo sapiens (human) |
Compounds (3)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| dorsomorphin | dorsomorphin : A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling. dorsomorphin: an AMPK inhibitor | aromatic ether; piperidines; pyrazolopyrimidine; pyridines | bone morphogenetic protein receptor antagonist; EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} inhibitor |
| ldn 193189 | LDN 193189: inhibits bone morphogenetic protein signaling | pyrimidines | |
| ml347 | ML347: an ALK2 inhibitor; structure in first source |