picolinic acid biosynthetic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways resulting in the formation of picolinic acid. [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19843166]

Picolinic acid biosynthesis is a metabolic pathway that produces picolinic acid, a pyridine derivative with various biological roles. The process typically starts with the amino acid L-tryptophan, which is first converted to quinolinate by the enzyme quinolinate synthase. Quinolinate is then transformed into picolinate by the enzyme quinolinate phosphoribosyltransferase. This step involves the removal of a carbon atom and the addition of a phosphoribosyl group. Picolinic acid can also be synthesized from other precursors like nicotinic acid or aspartic acid, but these pathways are less common. This biosynthetic process occurs in various organisms, including bacteria, fungi, and plants, and plays a vital role in cellular metabolism and defense against oxidative stress. Picolinic acid acts as a metal chelator, contributing to the detoxification of heavy metals. It also serves as a precursor for other important molecules like NAD+ and NADP+. In some organisms, picolinic acid also exhibits antimicrobial and antitumor activities.'
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Proteins (1)

Compounds (2)