picolinic acid biosynthetic process
Definition
Target type: biologicalprocess
The chemical reactions and pathways resulting in the formation of picolinic acid. [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19843166]
Picolinic acid biosynthesis is a metabolic pathway that produces picolinic acid, a pyridine derivative with various biological roles. The process typically starts with the amino acid L-tryptophan, which is first converted to quinolinate by the enzyme quinolinate synthase. Quinolinate is then transformed into picolinate by the enzyme quinolinate phosphoribosyltransferase. This step involves the removal of a carbon atom and the addition of a phosphoribosyl group. Picolinic acid can also be synthesized from other precursors like nicotinic acid or aspartic acid, but these pathways are less common. This biosynthetic process occurs in various organisms, including bacteria, fungi, and plants, and plays a vital role in cellular metabolism and defense against oxidative stress. Picolinic acid acts as a metal chelator, contributing to the detoxification of heavy metals. It also serves as a precursor for other important molecules like NAD+ and NADP+. In some organisms, picolinic acid also exhibits antimicrobial and antitumor activities.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase | A 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TDX5] | Homo sapiens (human) |
Compounds (2)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| diflunisal | diflunisal : An organofluorine compound comprising salicylic acid having a 2,4-difluorophenyl group at the 5-position. Diflunisal: A salicylate derivative and anti-inflammatory analgesic with actions and side effects similar to those of ASPIRIN. | monohydroxybenzoic acid; organofluorine compound | non-narcotic analgesic; non-steroidal anti-inflammatory drug |
| dipicolinic acid | dipicolinic acid : A pyridinedicarboxylic acid carrying two carboxy groups at positions 2 and 6. | pyridinedicarboxylic acid | bacterial metabolite |