negative regulation of sensory perception of bitter taste

Definition

Target type: biologicalprocess

Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of bitter taste. [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172]

Negative regulation of sensory perception of bitter taste is a complex biological process involving multiple cellular and molecular mechanisms. Bitter taste perception begins with the interaction of bitter compounds with taste receptor cells (TRCs) located in taste buds on the tongue. These TRCs express a diverse array of G protein-coupled receptors (GPCRs), specifically members of the TAS2R family, which are responsible for recognizing and binding to bitter compounds. Upon binding, the GPCRs activate intracellular signaling cascades, leading to the generation of electrical signals that are transmitted to the brain via gustatory nerves. Negative regulation of this pathway can occur at multiple levels. At the receptor level, desensitization of bitter taste receptors, such as through phosphorylation or internalization, can reduce the sensitivity of the receptor to bitter stimuli. Furthermore, a variety of mechanisms can attenuate downstream signaling pathways, such as the inhibition of G protein activation or the downregulation of downstream effector molecules. Additionally, neuronal adaptation occurs at the level of the gustatory neurons, where prolonged exposure to bitter stimuli can lead to a decrease in neuronal firing and sensitivity. This adaptive response contributes to the overall suppression of bitter taste perception. The negative regulation of bitter taste perception is crucial for maintaining homeostasis and avoiding the consumption of harmful substances. It enables the organism to adapt to varying environmental conditions and facilitate the consumption of palatable foods.'
"

Proteins (1)

Compounds (4)