negative regulation of wound healing, spreading of epidermal cells

Definition

Target type: biologicalprocess

Any process that stops, prevents or reduces the frequency, rate or extent of wound healing, spreading of epidermal cells. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891]

Negative regulation of wound healing, spreading of epidermal cells is a complex biological process that involves the coordinated action of multiple cell types and signaling pathways. It is characterized by a suppression of the normal wound healing response, leading to a delay or impairment in the closure of wounds. Specifically, the spreading of epidermal cells, which is a crucial step in re-epithelialization and wound closure, is negatively regulated. This suppression can occur through various mechanisms, including:

* **Inhibition of growth factor signaling**: Factors like epidermal growth factor (EGF) and transforming growth factor-beta (TGF-beta) play critical roles in promoting wound healing. Negative regulators can interfere with the signaling pathways of these growth factors, reducing their activity and hindering epidermal cell proliferation and migration.
* **Increased expression of inhibitors**: Several proteins act as inhibitors of wound healing, such as matrix metalloproteinase inhibitors (MMPIs) and tissue inhibitors of metalloproteinases (TIMPs). These proteins can block the activity of MMPs, which are essential for tissue remodeling and cell migration during wound healing.
* **Alteration of the extracellular matrix**: The extracellular matrix (ECM) provides structural support and guidance for migrating cells. Negative regulators can alter the composition and organization of the ECM, making it less conducive to cell migration and wound closure.
* **Immune cell dysfunction**: Immune cells like macrophages play a critical role in wound healing by removing debris, promoting angiogenesis, and releasing growth factors. Negative regulators can disrupt the function of these immune cells, impairing their ability to contribute to the healing process.
* **Increased inflammation**: While inflammation is essential in the early stages of wound healing, prolonged inflammation can hinder the healing process. Negative regulators can promote chronic inflammation, leading to delayed wound closure and scarring.

Overall, negative regulation of wound healing, spreading of epidermal cells is a multifaceted process that involves the disruption of various cellular and molecular events. Understanding these mechanisms is essential for developing therapies to treat wounds that fail to heal properly.'
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Proteins (1)

Compounds (1)