Okazaki fragment processing involved in mitotic DNA replication
Definition
Target type: biologicalprocess
Any DNA replication, Okazaki fragment processing that is involved in mitotic cell cycle DNA replication. [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]
Okazaki fragment processing is an essential step in the replication of DNA during mitosis. As DNA polymerase can only synthesize DNA in a 5' to 3' direction, the lagging strand is synthesized discontinuously in short fragments called Okazaki fragments. These fragments are initiated by a primer, usually an RNA molecule, and then extended by DNA polymerase. Once an Okazaki fragment is completed, it needs to be joined to the growing lagging strand. This process involves a series of enzymatic steps: 1) The RNA primer is removed by an enzyme called RNase H. 2) The gap created by primer removal is filled in by DNA polymerase. 3) The newly synthesized DNA fragment and the existing lagging strand are joined together by DNA ligase. This process of Okazaki fragment processing continues until the entire lagging strand is synthesized. The process ensures that both strands of the DNA molecule are replicated faithfully and accurately, ensuring that the genetic information is passed on correctly to daughter cells during mitosis.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| DNA ligase 1 | A DNA ligase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P18858] | Homo sapiens (human) |
Compounds (2)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| chloroquine | chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis. Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses. | aminoquinoline; organochlorine compound; secondary amino compound; tertiary amino compound | anticoronaviral agent; antimalarial; antirheumatic drug; autophagy inhibitor; dermatologic drug |
| ol-135 |