1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways involving 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate. [GO_REF:0000068, GOC:bhm, GOC:TermGenie, PMID:19037259]

The 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process is a crucial pathway involved in cellular signaling and regulation. It centers around the production and degradation of 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate (PIP2), a phosphoinositide that serves as a key signaling molecule. PIP2 is synthesized from phosphatidylinositol 4,5-bisphosphate (PIP2) by the action of phosphatidylinositol 3-kinase (PI3K), a lipid kinase that phosphorylates the 3'-hydroxyl group of PIP2. The resulting PIP3 acts as a second messenger, triggering downstream signaling cascades. These cascades involve the activation of various signaling proteins, including protein kinase B (Akt), which plays a critical role in cell survival, growth, and metabolism. PIP3 can be dephosphorylated back to PIP2 by the phosphatase PTEN, providing a mechanism for regulating PIP3 levels and thus controlling the downstream signaling pathways. The metabolic process of PIP2 is tightly regulated, ensuring that appropriate levels of this key signaling molecule are maintained within the cell. This regulation is crucial for maintaining cellular homeostasis and responding effectively to various stimuli. It is a complex process that involves numerous enzymes, including phosphatidylinositol 3-kinases, phosphatases, and lipases, and is further influenced by the presence of specific proteins and lipids.'
"

Proteins (1)

Compounds (4)