positive regulation of Lys63-specific deubiquitinase activity
Definition
Target type: biologicalprocess
Any process that activates or increases the frequency, rate or extent of Lys63-specific deubiquitinase activity. [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133]
Positive regulation of Lys63-specific deubiquitinase activity is a complex biological process that involves the modulation of enzymes known as Lys63-specific deubiquitinases (DUBs). These DUBs are essential for maintaining cellular homeostasis by removing ubiquitin chains from target proteins, specifically those linked via Lys63 linkages. This type of ubiquitination is typically associated with signaling pathways involved in DNA repair, endocytosis, and immune responses.
The positive regulation of Lys63-specific DUB activity can occur through various mechanisms:
1. **Activation of DUB enzymes:** Some DUBs may exist in an inactive state and require specific stimuli or interactions to become active. This activation could involve conformational changes, protein-protein interactions, or the removal of inhibitory factors.
2. **Increased DUB expression:** The levels of specific DUBs can be upregulated in response to cellular cues, such as stress or signaling pathways. This increased expression leads to a higher abundance of the DUB enzyme, enhancing its ability to remove Lys63-linked ubiquitin chains.
3. **Removal of DUB inhibitors:** Certain proteins can act as inhibitors of DUB activity, preventing them from functioning properly. The removal or inactivation of these inhibitors can positively regulate DUB activity by allowing the DUB to access and deubiquitinate its substrates.
4. **Post-translational modifications:** Modifications like phosphorylation or acetylation can alter the activity or stability of DUB enzymes. These modifications may enhance DUB activity by increasing its catalytic efficiency or preventing its degradation.
5. **Subcellular localization:** The localization of DUBs within the cell can influence their access to specific substrates. The movement of a DUB to a particular cellular compartment where its target proteins reside can promote its activity.
The positive regulation of Lys63-specific DUB activity plays a crucial role in maintaining cellular homeostasis and orchestrating cellular processes. Disruptions in this process can lead to various pathological conditions, highlighting the importance of understanding and regulating Lys63-specific DUB activity.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Transitional endoplasmic reticulum ATPase | A transitional endoplasmic reticulum ATPase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P55072] | Homo sapiens (human) |
Compounds (6)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| clotrimazole | conazole antifungal drug; imidazole antifungal drug; imidazoles; monochlorobenzenes | antiinfective agent; environmental contaminant; xenobiotic | |
| Methylenedioxycinnamic acid | hydroxycinnamic acid | ||
| 3,4-methylenedioxy-beta-nitrostyrene | 3,4-methylenedioxy-beta-nitrostyrene: tyrosine kinase inhibitor that prevents platelet glycoprotein IIb/IIIa activation; structure in first source | ||
| 4-(4-(4-chloro-phenyl)thiazol-2-ylamino)phenol | substituted aniline | ||
| ML240 | ML240 : A member of the class of quinazolines that is quinazoline which is substituted at positions 2, 5 and 8 by 2-amino-1H-benzimidazol-1-yl, benzylnitrilo and methoxy groups, respectively. It is a ATP-competetive inhibitor of AAA ATPase p97, also known as valosin-containing protein (VCP). | aromatic amine; aromatic ether; benzimidazoles; primary amino compound; quinazolines; secondary amino compound | antineoplastic agent |
| ganciclovir | 2-aminopurines; oxopurine | antiinfective agent; antiviral drug |