positive regulation of protein K63-linked deubiquitination

Definition

Target type: biologicalprocess

Any process that activates or increases the frequency, rate or extent of protein K63-linked deubiquitination. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133]

Positive regulation of protein K63-linked deubiquitination is a critical biological process involved in controlling the stability and activity of various cellular proteins. It involves the removal of K63-linked polyubiquitin chains from target proteins by deubiquitinases (DUBs). K63-linked ubiquitination is a distinct type of ubiquitination that does not typically lead to protein degradation but rather acts as a signaling mechanism.

The process of positive regulation of K63-linked deubiquitination involves a series of intricate steps.

1. **Target protein ubiquitination:** The target protein is initially modified by the addition of K63-linked polyubiquitin chains. This is typically mediated by E3 ubiquitin ligases that recognize specific motifs or modifications on the target protein.
2. **DUB recruitment:** Specific DUBs are recruited to the target protein, often through interaction with the K63-linked ubiquitin chains or other regulatory proteins.
3. **Deubiquitination activity:** The recruited DUBs possess catalytic activity that cleaves the isopeptide bonds between ubiquitin monomers within the K63-linked chains. This process removes the ubiquitin chains from the target protein.
4. **Signal modulation:** The removal of K63-linked ubiquitin chains alters the signaling state of the target protein. It can influence its stability, activity, localization, or interactions with other proteins.

The positive regulation of K63-linked deubiquitination plays a crucial role in a wide range of cellular processes, including:

* **Signal transduction:** K63-linked ubiquitination is involved in various signaling pathways, such as those regulating inflammation, immunity, and DNA damage response. DUBs can modulate these pathways by removing K63-linked ubiquitin chains, fine-tuning signal intensity and duration.
* **DNA repair:** K63-linked ubiquitination marks damaged DNA regions, promoting the recruitment of repair proteins. DUBs can then remove these ubiquitin tags, allowing for the completion of DNA repair and the restoration of genomic integrity.
* **Protein trafficking:** K63-linked ubiquitination is also implicated in the sorting and trafficking of proteins within the cell. DUBs can regulate this process by removing ubiquitin chains, influencing protein localization and destination.
* **Immune response:** K63-linked ubiquitination plays a key role in the immune response, regulating the activity of immune signaling pathways and the activation of immune cells. DUBs can modulate these pathways by removing K63-linked ubiquitin chains, controlling the intensity and duration of immune responses.

Overall, positive regulation of protein K63-linked deubiquitination is a complex and highly regulated process essential for maintaining cellular homeostasis and proper cellular function. Deregulation of this process can lead to various diseases, underscoring its importance in health and disease.'
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Proteins (1)

Compounds (6)