negative regulation of muscle tissue development

Definition

Target type: biologicalprocess

Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development. [GOC:TermGenie, GOC:yaf, PMID:23150719]

Negative regulation of muscle tissue development involves a complex interplay of signaling pathways, transcription factors, and microRNAs that precisely control the timing and extent of muscle cell differentiation and growth. This process is essential for the formation of functional muscles and for maintaining their integrity throughout an organism's life. Here's a breakdown of the key mechanisms involved:

- **Signaling Pathways:**
- **Wnt Signaling:** The canonical Wnt pathway promotes muscle progenitor cell proliferation and inhibits differentiation. Inhibition of Wnt signaling is crucial for the transition from proliferation to differentiation.
- **TGF-β Signaling:** TGF-β superfamily members like myostatin play a key role in inhibiting muscle growth. They can induce muscle atrophy and limit muscle fiber size.
- **Hedgehog Signaling:** The Hedgehog pathway plays a complex role in muscle development, both promoting and inhibiting different aspects. Its involvement in negative regulation is not fully understood.
- **Notch Signaling:** Notch signaling contributes to the maintenance of muscle progenitor cell populations and can regulate muscle differentiation in specific contexts.

- **Transcription Factors:**
- **Myostatin:** A key negative regulator of muscle growth, Myostatin inhibits the expression of genes involved in muscle fiber formation and growth.
- **Foxo Transcription Factors:** Foxo proteins are activated by various signaling pathways (like insulin and IGF-1 signaling) and can induce muscle atrophy.
- **NF-κB:** This transcription factor is activated in response to stress and inflammation and can inhibit muscle growth and promote atrophy.

- **MicroRNAs:**
- **miR-206:** A key microRNA in muscle differentiation, miR-206 targets genes involved in proliferation and inhibits muscle differentiation.
- **miR-486-5p:** This microRNA has been shown to regulate muscle fiber size and may contribute to muscle atrophy.

- **Other Factors:**
- **Epigenetic Modifications:** Changes in DNA methylation and histone acetylation can influence gene expression patterns and impact muscle development.
- **Oxygen Availability:** Hypoxia can lead to the downregulation of muscle growth factors and induce muscle atrophy.

Negative regulation of muscle tissue development is a dynamic process that involves complex interactions between different signaling pathways, transcription factors, and microRNAs. This intricate regulation ensures that muscles develop correctly and maintain their functional integrity. Understanding these mechanisms is crucial for developing therapies for muscle disorders and for optimizing muscle growth and function in different contexts.'
"

Proteins (1)

Compounds (3)