regulation of lymphocyte chemotaxis

Definition

Target type: biologicalprocess

Any process that modulates the frequency, rate or extent of lymphocyte chemotaxis. [GOC:TermGenie]

Lymphocyte chemotaxis, the directed migration of lymphocytes towards a chemical gradient, is a crucial process in immune responses. It involves a complex interplay of signaling pathways, cytoskeletal rearrangements, and adhesion molecules. The process begins with the detection of chemoattractants, such as chemokines, by specific receptors on the lymphocyte surface. These receptors activate intracellular signaling cascades, leading to the generation of second messengers like diacylglycerol (DAG) and inositol trisphosphate (IP3). DAG activates protein kinase C (PKC), which phosphorylates various downstream targets, including cytoskeletal proteins and adhesion molecules. IP3 triggers the release of calcium ions from intracellular stores, leading to an increase in intracellular calcium concentration. This calcium influx further activates signaling pathways, contributing to cytoskeletal rearrangements. The activation of these signaling pathways results in the polymerization of actin filaments, forming a leading edge at the front of the lymphocyte. This leading edge extends pseudopodia, finger-like projections that probe the environment for the chemoattractant source. Concurrently, the lymphocyte utilizes adhesion molecules, such as integrins, to bind to the extracellular matrix or other cells, providing traction for migration. The coordinated actions of these signaling pathways, cytoskeletal rearrangements, and adhesion molecules allow the lymphocyte to move directionally towards the chemoattractant source. The process of lymphocyte chemotaxis is highly regulated, ensuring that lymphocytes migrate to the appropriate site of inflammation or infection, enabling effective immune responses. '
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Proteins (1)

Compounds (1)